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generative-ai

Mentors and Regional Facilitators
Name Region Skills Interests
Aniruddha Maiti ACCESS CSSN, Campus Champions
Devin Bayly ACCESS CSSN, Campus Champions, CCMNet
Brandon Biggs OnDemand
David Liu CCMNet
David Ryglicki
Fan Chen ACCESS CSSN
Feseha Abebe-Akele CCMNet
Mattie Niznik Campus Champions
Dr. Nabeel Alzahrani Campus Champions, CCMNet

Affinity Groups

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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Amira Kefi

University of Illinois at Chicago

Programs

CCMNet

Roles

CCMNet

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Expertise

Mattie Niznik

Programs

Campus Champions

Roles

research computing facilitator

A picture of Mattie wearing red glasses and dressed for winter

Expertise

Dr. Nabeel Alzahrani

California State University-San Bernardino

Programs

Campus Champions, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, ci systems engineer, CCMNet

Headshot

Expertise

People with Interest

ali eydgahi

Programs

CCMNet

Roles

CCMNet

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Interests

Micholas Smith

University of Tennessee, Knoxville

Programs

ACCESS CSSN

Roles

cssn, CIP

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Interests

Vikram Gazula

University of Kentucky

Programs

ACCESS CSSN, CCMNet, Campus Champions, Kentucky, OnDemand

Roles

mentor, regional facilitator, research computing facilitator, Affinity Group Leader, KB PM, CCMNet PM, CCMNet

Vikram

Interests